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Technology Transfer and Intellectual Property

The Office of Technology Transfer is responsible for identifying clinically or commercially significant research activities arising at Baystate, ensuring that such developments are protected via the most appropriate route (e.g. patents, copyrights, etc.), and working with industry to promote the development of beneficial products from Baystate's research and inventions.

Technology Transfer Officer

Todd Keiller, MBA
Office: 508-395-4221


IP Policy
IP Participation Agreement
IP Disclosure Form

Products on the Market

Products on the Market

Several Baystate-developed technologies are already on the market and are being made commercially available by our licensees. 

Agilent XF Cell Mito Stress Test Kit

Inventors: Nagendra Yadava, Ph.D., Chul Kim, Ph.D. and Alejandro Heuck, Ph.D (UMass-Amherst)

This invention is an improvement to existing methods in which the function of mitochondria or other internal cellular organelles can be assayed in situ, without lysing the cell or otherwise disturbing the cell’s overall integrity. Such methods have been carried out using agents that can permeabilize cell membranes, such as digitonin or saponin, but these methods have several drawbacks, including negative effects on mitochondrial function, as well as cytotoxicity in some cases. 

Such assays can be used to study mitochondrial function/metabolism in muscle fibers, cell lines, and primary cells, for purposes such as assaying oxidative phosphorylation complexes, TCA cycle reactions/function, and mitochondrial permeability transition, and can also be used to study other organelles such as lysosomes and the endoplasmic reticulum. 

Mitochondrial dysfunction is associated with many diseases including neurodegeneration, cancer and diabetes, and the role of mitochondria in human disease is increasingly being appreciated. 

Licensed and sold by Agilent Technologies.

Solution to Psychological Insulin Resistance (SPIR)

The SPIR program is conceptualized as an integrated patient and provider assessment and treatment program to overcome the clinical problem of Psychological Insulin Resistance and improve evidence-based insulin management for diabetes in primary care clinics within a comprehensive diabetes care model. This program is the culmination of years of research by Baystate investigator, Gary Welch, Ph.D

Silver Fern Healthcare, LLC
11 Northmoor Road
West Hartford, CT 06117

Improved Devices for Natural Orifice Translumenal Endoscopic Surgery (NOTES)

Dr. David Desilets of Baystate has developed and tested two innovative surgical devices for use in Natural Orifice Translumenal Endoscopic Surgery (NOTES), both of which were jointly invented with engineers at a well-known surgical device company. Baystate has entered into license agreements with this company for the development and commercialization of these devices.

Exclusive license to surgical device company.

Integrated Dynamic GIS Mapping Extension for Medical Crisis Information Management System

Baystate, through its for-profit off-shoot Baystate Health Geographics, has collaborated with Global Emergency Resources, Inc. to create an improved Medical Crisis Information Management System (M-CIMS).

This new system integrates M-CIMS with dynamic Geographical Information Systems (GIS) technology to provide healthcare disaster managers with access to the right information, in the right format and at the right time, to create an “infosphere of healthcare preparedness” at the national, regional, state, local or institutional level.

This system has been incorporated into Global Emergency Resources’ product HC Standard, which is the first truly specialized web-based Medical Crisis Information Management Software. Baystate Health Geographics is internationally recognized for “pushing the GIS envelope” in the areas of hospital healthcare and “hospital-land” security.

Global Emergency Resources
2910-B Professional Parkway
Augusta, GA 30907
phone 866-404-6911

Inventions for License

Inventions for License

Baystate maintains a portfolio of pending patent applications and other inventions that are available for licensing to for-profit companies.

Electronic Rounds Software Program for At-risk Subjects

Invention: BH-037 | Inventor: Angelo Pananas, LMHC

The current method of documenting check in or “rounding” on at risk subjects is done via a paper method. This is uniform across psychology wards. The Electronic Rounds Software Program is an electronic replacement via a tablet or other hand held device. The program offers improved accuracy, accountability, and data retention as compared to traditional methods. It is hypothesized this program will reduce instances of self-harm behaviors through several previously unachievable by traditional paper methods.

Improved Foley Catheter Design

Invention: BH-043 | Inventor: Mary Buttita, RN

This patent pending design modifies the current Foley catheter to decrease potential exposure to infection. The catheter has a protective applicator tip for insertion, which allows the catheter to not be contaminated during insertion. There is a secondary balloon that is inflated after the internal balloon in the bladder is inflated. The secondary ballon is external and prevents the catheter from re-entering the urethra. The protective plastic sheath and the tip break away after insertion and are disposed of.

P53 Silenced Entothelial Progenitor Cells (EPC) Improve Collateral Circulation

Invention: BH-028 | Inventor: Sabyasachi Sen, MD, Ph.D.

Literature shows that EPCs contribute to increased collateral vessel formation following vaso-occlusion. However diabetes reduces EPC number and reduces collateral vessel formation. We cultured human EPCs and exposed them to 5.5 mM (equivalent to 99mg%) and 20mM (equivalent to 360mg%, HG) glucose, which resulted in significant EPC death within 48hrs. We noted HG exposure was associated with up-regulation of P53 and its downstream genes such as P21, PUMA and Caspase-3. We hypothesized that EPC reduction in hyperglycemia is secondary to up-regulation of pro-apoptotic gene, P53. Transplantation of P53 null EPCs in hyperglycemic mice with femoral occlusion demonstrate better collateral vessel formation post femoral artery occlusion setting compared to WT-EPC transplanted group.

In diabetic mouse models our findings demonstrate the possible therapeutic benefit of transplanting short-term p53 silenced EPC to prevent peripheral vascular disease by increasing collateral vessel formation in patients with diabetes

Targeted Education Project

Invention: BH-40 | Inventor: Ruchi Thanawala, MD

The Targeted Education Project is a software product that provides clinical activity-specific content to users near the point-of-event. By utilizing information surrounding a clinician’s activities (e.g. OR schedule, patient characteristics, office schedule, computerized order entries), targeted information (e.g. journal articles, open articles, videos, images, etc.) will be delivered to the clinician in an automated fashion over email with the option of text message alerts. The information in the schedule builder will provide the base content to permit automated case logging, as required by the ACGME and American Board of Surgery, for the resident and the attending surgeon. Additionally, the CPT code used for the case logging will generate editable billing forms available for surgeons to submit.

Intellectual Property Policy