Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS)

The VItamin C, Thiamine And Steroids in Sepsis (VICTAS) Study is a double-blind, placebo-controlled, adaptive randomized clinical trial designed to investigate the efficacy of the combined use of vitamin C, thiamine and corticosteroids versus indistinguishable placebos for patients with sepsis. The objective of this study is to demonstrate the efficacy of combination therapy using vitamin C, thiamine and corticosteroids in reducing mortality and improving organ function in critically ill patients with sepsis.


This research study is led by Dr. Jay Steingrub.

Contact: Lori Ann Kozikowski, RN, 413-794-5584

Participation details:

August 22, 2018
Pulmonary/ Critical Care
Baystate Medical Center, 759 Chestnut St, Springfield, MA

Inclusion Criteria:

  • Suspected or confirmed infection as evidenced by ordering of blood cultures and administration of at least one antimicrobial agent
  • Anticipated or confirmed intensive care unit (ICU) admission

Exclusion Criteria:

  • Organ dysfunction present > 24 hours at time of enrollment
  • Current hospitalization > 30 days at time of randomization
  • Chronic hypoxemia requiring supplemental non-invasive oxygen (nasal cannula or NIPPV) or home mechanical ventilation
  • Chronic disease/illness that, in the opinion of the site investigator, have an expected lifespan of < 30 days unrelated to current sepsis diagnosis (e.g., stage IV malignancy, neurodegenerative disease, etc.)
  • Pregnant or actively breastfeeding
Interventional (Clinical Trial), Randomized