Pulmonary and Critical Care Medicine

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D14122 Phase II study of Pre-emptive OsciLLation of ER activitY levels through alternation of estradiol/anti-estrogen therapies prior to disease progression in ER+/HER2- metastatic breast cancer (POLLY)

Lead Researcher: Grace Makari-Judson, MD

Condition/Disease: Cancer - Breast, Cancer

Location:

D'Amour Center for Cancer Care

3350 Main Street
Springfield, MA 01199

A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients with Multivessel Coronary Artery Disease: Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 Trial

The purpose of this study is to demonstrate that Fractional Flow Reserve (FFR)-guided Percutaneous Coronary Intervention (PCI) is non-inferior to coronary artery bypass graft surgery (CABG) in patients with multi-vessel Coronary Artery Disease (CAD). FFF-guided PCI might result in lower rates of death, heart attack, and the need for repeat revascularization as compared to what was seen after CABG surgery. There is also the possibility of a chance at a shorter recovery time with the minimally invasive FFR-guided PCI versus CABG surgery.

Lead Researcher: Dr. Amir Lotfi

Condition/Disease: Heart

Location:

Baystate Medical Center 759 Chestnut Street Springfield, MA 01199

A Double-blind, Randomised, Placebo-controlled, Phase 2b/3 Adaptive Clinical Trial Investigating the Efficacy and Safety of Selepressin as Treatment for Patients with Vasopressor-dependent Septic Shock

Lead Researcher: Mark Tidswell, MD

Condition/Disease: Infection

Location:

Baystate Medical Center

759 Chestnut Street

Springfield, MA 01199

A Home Based Study to Enhance Activity in Breast Cancer Survivors

Lead Researcher: Grace Makari-Judson, MD

Condition/Disease: Cancer, Cancer - Breast

Location:

D'Amour Center for Cancer Care

3350 Main Street
Springfield, MA 01199

A Multi-Center Evaluation Of The Delivery Of Intracoronary Hyperoxemic Supersaturated Oxygen Therapy For 60 Minutes In Anterior Acute Myocardial Infarction Patients With Successful Reperfusion (Via PCI) ≤ Six Hours After Symptom Onset

Lead Researcher: Amir Lotfi, MD

Condition/Disease: Heart

Location:

Baystate Medical Center

759 Chestnut Street

Springfield, MA 01199

A PHASE II EVALUATION OF COPANLISIB (BAY 80-6946) (IND #130822), A SELECTIVE INHIBITOR OF PI3KCA, IN PATIENTS WITH PERSISTENT OR RECURRENT ENDOMETRIAL CARCINOMA HARBORING PIK3CA HOTSPOT MUTATIONS

Lead Researcher: James Hoffman, MD

Condition/Disease: Cancer, Cancer-Gynecologic

Location:

D'Amour Center for Cancer Care

3350 Main Street
Springfield, MA 01199

A PHASE III, MULTICENTER, RANDOMIZED, STUDY OF ATEZOLIZUMAB VERSUS PLACEBO ADMINISTERED IN COMBINATION WITH PACLITAXEL, CARBOPLATIN, AND BEVACIZUMAB TO PATIENTS WITH NEWLY-DIAGNOSED STAGE III OR STAGE IV OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER (GOG 3015)

Lead Researcher: James Hoffman, MD

Condition/Disease: Cancer-Gynecologic, Cancer

Location:

D'Amour Center for Cancer Care

3350 Main Street
Springfield, MA 01199

A Phase 1b/2a, Randomized, Double-Blinded, Placebo-Controlled, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Subjects with Severe Sepsis

The purpose of this study is to evaluate the safety and potential efficacy signal of the study drug, BMS-936559, in subjects with severe sepsis.

Lead Researcher: Tidswell, Mark, MD

Condition/Disease: Infection

Location:

Baystate Medical Center 759 Chestnut Street Springfield, MA 01199

A Phase II Study of Talazoparib (BMN 673) in Patients with Homologous Recombination Repair Deficiency Positive Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study)

Lead Researcher: John McCann, MD

Condition/Disease: Cancer, Cancer - Lung

Location:

D'Amour Center for Cancer Care

3350 Main Street
Springfield, MA 01199

A Phase II Trial Evaluating Cisplatin (NSC #119875) And Gemcitabine (NSC # 613327) Concurrent With Intensity-Modulated Radiation Therapy (IMRT) In The Treatment Of Locally Advanced Squamous Cell Carcinoma Of The Vulva

The purpose of this study is to find out if radiation therapy along with the addition of the drugs, cisplatin and gemcitabine, works and to find out what side effects or surgical complications are caused by treatment with this combination.

Lead Researcher: Tashanna Myers, MD

Condition/Disease: Cancer-Gynecologic, Cancer

Location:

D’Amour Center for Cancer Care

3350 Main Street, Springfield MA 01199

Franklin Medical Center

164 High Street, Greenfield MA

Page 1 of 9 | Results 1 - 10 of 82