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Patients and Visitors Learn About Clinical Trials Find a Clinical Trial Pulmonary and Critical Care Medicine

Pulmonary and Critical Care Medicine

Page 1 of 6 | Results 1 - 10 of 60

A Metastatic breast cancer trial

Grace Makari-Judson, MD
Cancer - Breast, Cancer

D'Amour Center for Cancer Care
3350 Main Street
Springfield, MA 01199

A Phase II trial to study Stage IV Squamous Cell Lung Cancer (Lung-MAP study)

John McCann, MD
Cancer, Cancer - Lung

D'Amour Center for Cancer Care
3350 Main Street
Springfield, MA 01199

A Phase III trial evalutaing use of adjuvant endorcrine therapy in patients with high-risk hormone receptor-positive and HER2/negative Breast Cancer

The purpose of this study is to see whether treatment with everolimus plus hormone treatment after chemotherapy will increase the time without your cancer returning.  The current standard treatment after chemotherapy is hormone treatment alone. The combination of hormone-treatment and everolimus is experimental in patients with breast cancer.
Grace Makari-Judson, MD
Cancer - Breast, Cancer

D’Amour Center for Cancer Care
3350 Main Street
Springfield, MA 01199

A Phase III trial to assess efficacy and safety of chemotherapy as an adjuvant treatment for patients with BRCA1/2 Mutations and high risk Her2 negative primary breast cancer

Grace Makari-Judson, MD
Cancer, Cancer - Breast

D’Amour Center for Cancer Care
3350 Main Street
Springfield MA 01199

A Phase III trial to study post-operative radiation therapy for endometrial and cervical cancer

The purpose of this study is to test whether the use of a radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can reduce the amount and severity of gastrointestinal side effects (such as diarrhea) that result from radiation, compared with standard radiation techniques
Seth Kaufman, MD
Cancer-Gynecologic, Cancer

D’Amour Center for Cancer Care
3350 Main Street
Springfield MA 01199

A Randomized Phase II Study of Perioperative mFOLFIRINOX (study drug) versus Gemcitabine/nab-Paclitaxel (study drug) as Therapy for Resectable Pancreatic Adenocarcinoma

The purpose of this study is to compare the effects of mFOLFIRINOX (oxaliplatin, irinotecan, and fluorouracil) and gemcitabine plus nab-paclitaxel. These chemotherapy drugs will be given before and after surgery. This study will allow the researchers to know if it is a good idea to treat pancreatic cancer with chemotherapy drugs before surgery and if so, to see which of the two drug combinations is better.
Chandravathi Loke, MD
Cancer - Pancreatic, Cancer

D'Amour Center for Cancer Care
3350 Main Street
Springfield, MA 01199

A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

This study evaluates whether the addition of chestwall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for invasive breast cancer recurrence-free interval (IBC-RFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

Seth Kaufman, MD
Cancer - Breast

D'Amour Center for Cancer Care 

A Randomized Phase Iii Study Of Bendamustine Plus Rituximab Versus Ibrutinib Plus Rituximab Versus Ibrutinib Alone In Untreated Older Patients (¡ý 65 Years Of Age) With Chronic Lymphocytic Leukemia (CLL)

The purpose of this study is to compare the effects, good and/or bad, of the drug ibrutinib, either alone or in combination with the drug rituximab, with the standard treatment for this disease.
Syed Ali, MD
Cancer - Leukemia

 D’Amour Center for Cancer Care

3350 Main Street

Springfield MA 01199


Franklin Medical Center

164 High Street

Greenfield MA 

A comparative study of two groups of chemotherapy agents for melanoma

The purpose of this research study is to compare any good and bad effects of giving ipilimumab, nivolumab, and GM-CSF (Sargramostim) at the same time compared to just ipilimumab and nivolumab together. We would also like to find out what effects, good and bad, that this combination of drugs may have on your cancer.
John McCann, MD
Cancer - Melanoma, Cancer

D'Amour Center for Cancer Care
3350 Main Street
Springfield, MA 01199

A comparison of fractional flow reserve vs. coronary (heart) Angiography for coronary multivessel evaulation

The purpose of this study is to demonstrate that Fractional Flow Reserve (FFR)-guided Percutaneous Coronary Intervention (PCI) is non-inferior to coronary artery bypass graft surgery (CABG) in patients with multi-vessel Coronary Artery Disease (CAD). FFF-guided PCI might result in lower rates of death, heart attack, and the need for repeat revascularization as compared to what was seen after CABG surgery. There is also the possibility of a chance at a shorter recovery time with the minimally invasive FFR-guided PCI versus CABG surgery.
Dr. Amir Lotfi
Heart

Baystate Medical Center
759 Chestnut Street
Springfield, MA 01199

Page 1 of 6 | Results 1 - 10 of 60