Door To Unloading With IMPELLA CP System in Acute Myocardial Infarction to Reduce Infarct Size (DTU): A Prospective Feasibility Study

1112813
Heart
Evan Lau, MD
Davis Family Heart & Vascular Center
Baystate Medical Center
759 Chestnut Street
Springfield, MA 01199
Direct active unloading of the left ventricle with the Impella CP System prior to PPCI in patients with ST-elevation myocardial infarction (STEMI) is safe and feasible

Ages Eligible for Study:

21 Years to 80 Years (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Main Inclusion Criteria:

Age 21-80 years

First myocardial infarction

Acute anterior STEMI with ≥ 2 mm in 2 or more contiguous anterior leads or≥ 4 mm total ST-segment deviation sum in the anterior leads

Signed Informed Consent

 

Main Exclusion Criteria:

Cardiogenic shock defined as: systemic hypotension (systolic BP less than 90 mmHg or the need for inotropes/pressors to maintain a systolic BP Greater than 90mmHg) plus one of the following: any requirement for pressors/inotropes prior to arrival at the cath lab, clinical evidence of end organ hypoperfusion, lactate level greater than 2.5mmol/L

Inferior STEMI or suspected right ventricular failure

Suspected or known pregnancy

Suspected active infection

History or known hepatic insufficiency prior to catheterization

On dialysis therapy

Known contraindication to:

Undergoing MRI or use of gadolinium

Heparin, pork, pork products or contrast media

Receiving a drug-eluting stent

Participation in the active treatment or follow-up phase of another clinical study of an investigational drug or device

Inpatient
Annette Scarnici, RN
413-794-9076