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A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients with Multivessel Coronary Artery Disease: Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 Trial

939598
Heart
Dr. Amir Lotfi

Baystate Medical Center 759 Chestnut Street Springfield, MA 01199

The purpose of this study is to demonstrate that Fractional Flow Reserve (FFR)-guided Percutaneous Coronary Intervention (PCI) is non-inferior to coronary artery bypass graft surgery (CABG) in patients with multi-vessel Coronary Artery Disease (CAD). FFF-guided PCI might result in lower rates of death, heart attack, and the need for repeat revascularization as compared to what was seen after CABG surgery. There is also the possibility of a chance at a shorter recovery time with the minimally invasive FFR-guided PCI versus CABG surgery.

1. 21 years with angina and/or evidence of myocardial ischemia.

2. Three vessel CAD, defined as ≥ 50% diameter stenosis by visual estimation in each of the three major epicardial vessels or major side branches, but not involving left main coronary artery, and amenable to revascularization by both PCI and CABG as determined by the Heart Team. Patients with a non-dominant right coronary artery may be included if only the left anterior descending artery (LAD) and left circumflex have ≥ 50% stenosis.

Dr. Amir Lotfi
413-794-4490