Characterization of de novo Marker Chromosomes Associated with
Cancer and Congenital Abnormalities.
Abel Ponce de Leon, Ph.D., Veterinary and
Animal Sciences, UMass
Rizwan Naeem, M.D., Pathology, Baystate
Marker chromosomes are chromosomes whose genetic constitution can
not be determined by conventional cytogenetic techniques. Marker
chromosomes of de novo origin are of particular concern when identified
in fetal cells during prenatal diagnosis. These chromosome markers
are often found in some of the most common and devastating cancers
like breast and prostate cancer.
Effective November 1, 1995
Regulation of p53 Tumor Suppressor Pathway in Normal and Neoplastic
Breast Tissues
Joseph Jerry, Ph.D., Veterinary & Animal Sciences, UMass
Stephen Naber, M.D., Ph.D., Pathology, Baystate
Jan Pinkas, Graduate Student, Molecular & Cellular Biology,
UMass
The p53 suppressor gene is mutated or expressed aberrantly in over
half of all breast cancers. An objective of this study is to determine
whether expression of the p53 tumor suppressor gene may be inhibited
or enhanced during specific periods of breast development.
Effective - November 1, 1995
Extramural Funding:
DPH Mass – (1/96 – 12/96) - $50,715
PHS/NIH – (6/96 to 6/02) - $524,661
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